Homeostatic Design
Homeostatic signaling systems must be tailored to the unique properties of each cell type in the brain. In general, homeostatic signaling systems are based on feedback control, an outline of which is diagrammed below. This simple diagram serves to highlight the many questions that remain unanswered despite our recent progress. Ultimately, homeostatic signaling in the brain is likely to involve many interconnected systems such as this, inclusive of not only feedback but also feedforward signaling, and the incorporation of many reversible and irreversible enzymatic reactions.
Homeostatic Plasticity and the Mechanisms of Disease
Anatomical illustration by Leonardo da Vinci